Synthesis and Biological Evaluation of Pyrazole Derivatives As Antidiabetic Agents

Abstract

The rising menace of diabetes mellitus (type 2) has fuelled the quest to seek safer and more effective treatment options. Within this framework, the given research study was carried out with regard to designing, synthesis, characterization, and biological study of novel pyrazole derivatives as a potential antidiabetes drug. A series of 12 compounds has been produced by the process consisting of multi-step organic reaction which involves hydrazines, 10betabdiketones and aldehydes which are substituted. Analysis by FTIR, NMR, UV, and LC-MS was done to determine the structural characterization. The in vitro screening showed that several derivatives were found to be of great concern to α -amylase and α-Glucosidase inhibitor with PZ-09 having the IC50 values equivalent to acarbose. Further in vivo experiments with diabetic Wistar rats, induced by streptozotocin, showed that PZ-06 and PZ-09 decreased significantly the fasting blood glucose values during the 14-day use and this value was comparable to that of metformin. These results suggest that pyrazole derivatives, especially PZ-09 can be potentially used as multifunctional scaffold materials in the design of next-generation of antidiabetic agents.